Lu Jun is the first SCM student to receive the First Prize at the “Challenge Cup” National College Students’ Extracurricular Academic Science and Technology Works Contest


魯軍同學是中醫藥學院首位贏得「挑戰杯」全國大學生課外學術科技作品競賽一等獎的學生

Date: 01 Dec 2017 (Friday)

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Chinese medicine PhD student wins first prize in “Challenge Cup” National College student contest

中醫藥博士生喜獲「挑戰杯」全國大學生競賽一等獎

Lu Jun, a PhD student of the School of Chinese Medicine (SCM), recently won the First Prize for his research thesis in the Fifteenth “Challenge Cup” National College Students’ Extracurricular Academic Science and Technology Works Contest held in Shanghai University. He is the first SCM student to receive this prize. His award-winning project is entitled “Develop a Highly Water Soluble Nucleolin Aptamer Paclitaxel Conjugate with a Cathepsin Labile Linker for Tumour Specific Targeting in Breast Cancer”.

The project mainly studied the preparation of a conjugate containing a cathepsin labile linker that linked up paclitaxel (PTX) with nucleolin aptamer (NucA). This conjugate exhibited great water solubility, homogeneity and storage stability. The NucA modification facilitated the selective accumulation of the conjugated PTX in tumour tissues, resulting in notably improved antitumour activity and reduced toxicity. This work laid the foundation for the development of a new generation of aptamer-drug conjugate.

Dubbed the Olympic for college students’ science and technology innovations, the “Challenge Cup” National College Students’ Extracurricular Academic Science and Technology Works Contest is organised biennially by the China Association for Science and Technology, the Ministry of Education and other organisations that aims at fostering the development of young innovative talents.

This year, the competition attracted contestants from more than 2,000 higher education institutions to submit over 600,000 science and technology innovation projects. After the preliminary rounds of the Contest, a total of 1,230 projects were shortlisted for the final round, among which 102 projects were awarded the First Prize.

中醫藥學院博士研究生魯軍同學憑研究論文「一種具有良好水溶性,酶敏感性,腫瘤靶向性的智慧型抗乳腺癌藥物─適配子─紫杉醇偶合物」,最近榮獲在上海大學舉行的第15屆「挑戰杯」全國大學生課外學術科技作品競賽一等獎,是中醫藥學院首位贏得此獎項的學生 。

魯軍同學的得獎論文主要研究利用蛋白酶敏感的二肽鍵將紫杉醇與核仁素適配子偶聯起來,形成具有良好水溶性和腫瘤靶向性的適配子紫杉醇偶合物,以增強對腫瘤細胞的毒性,並大大降低對正常細胞的損害,這種設計為開發新一代適配子藥物偶合物奠定了基礎。

「挑戰杯」全國大學生課外學術科技作品競賽被譽為當代大學生科技創新的「奧林匹克」盛會,每兩年舉辦一次,由中國科協、教育部等機構主辦,旨在促進青年創新人才成長。今年競賽共有來自2,000多所高校逾60萬個科技創新作品參加,經初賽及複賽後選出1,230個作品進入決賽,最後共有102件作品獲頒一等獎。