Dr Zhang Ge receives recognition again for his related research on bones and wins the second prize in Chinese Medical Science and Technology Award (2014)


張戈博士的相關骨質聯合研究再獲殊榮,獲得「2014年中華醫學科技獎」二等獎

Date: 04 Mar 2015 (Wednesday)

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Dr Zhang Ge of School of Chinese Medicine wins the second prize of Chinese Medical Science and Technology Award (2014)

中醫藥學院張戈博士骨質聯合研究獲「2014年中華醫學科技獎」二等獎

Dr Zhang Ge, Director of the Technology Development Division and Associate Director of the Teaching Division of the School of Chinese Medicine, and Deputy Director of the Institute for Advancing Translational Medicine in Bone and Joint Diseases, recently won the second prize in Chinese Medical Science and Technology Award (2014) presented by the Chinese Medical Association for his project conducted in collaboration with the Institute of Radiation Medicine of Academy of Military Medical Sciences in Beijing, The Chinese University of Hong Kong, and Astronaut Research and Training Center of China.  

In the award-winning project entitled “Investigation of regulatory mechanism of ubiquitin ligases and their application in the treatment of osteoporosis”, researchers found that the “CKIP-1” factor can inhibit bone formation while the factor “SCFFBXL15” can enhance bone formation. It has also been found that the delivery system “(DSS)6-liposome” helps promote bone anabolic action of osteogenic siRNAs.  

Dr Zhang Ge said that the project has revealed the regulatory mechanism of ubiquitin ligases and identified various potential molecule targets for the treatment of osteoporosis. He said that the award is a source of great encouragement for the team, which will continue to spare no efforts in research leading to the development of effective new drugs.

中醫藥學院技術開發部主任、教學部副主任兼骨與關節疾病轉化醫學研究所副所長張戈博士與北京的軍事醫學科學院放射與輻射醫學研究所、香港中文大學和宇航員科研訓練中心聯合進行的一項研究項目,最近獲得由中華醫學會頒發的2014年中華醫學科技獎」二等獎  

得獎的研究項目為「蛋白質泛素化修飾的調控機制及其在骨質疏鬆促骨形成治療中的應用」。研究人員發現人體內一種名為「CKIP-1」的分子能夠有效抑制骨的形成,另一種名為「SCFFBXL15」的分子則有促進骨形成的功用,而遞送系統「(DSS)6-liposome也發揮了促進成骨siRNA骨形成的作用。  

博士指出,這項研究揭示了蛋白質泛素連接酶的調控機制,並確定了骨質疏鬆治療的若干潛在藥物靶點,有助科研人員進一步展開針對性的轉化醫學研究。他認為獎項肯定了研究團隊的貢獻,研究人員將繼續努力不懈,希望最終能達致研發有效新藥的目標。