(from left) David Chan, Sun Xizhen, Leng Houfu, Liang Tianlun, Zhang Junqing and Zou Yukai appreciate the memorable experience of working on the project which was filled with learning, encouragement and growth


(左起)陳宗駒、孫希震、冷厚甫、梁天倫、張珺卿和鄒煜凱都認為過程給予他們學習、互相鼓勵和成長的難忘經歷。

The team presents their project results to the competition organiser in the US


浸大隊遠赴位於美國的主辦單位展示項目成果

Date: 13 Nov 2013 (Wednesday)

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HKBU students' design of innovative biomedical technology at BIOMOD 2013 wins Silver Project Award

浸大生設計生物醫學創新技術    國際生物分子設計比賽奪銀獎

Six HKBU students from four specialties formed a team called The Rising Power which recently won the Silver Project Award at the 2013 International Bio-molecular Design Competition (BIOMOD 2013). The HKBU team is the only winning team from Hong Kong among 26 competing teams from nine countries.

The team designed a self-assembled DNA origami biological marker which was conjugated with quantum dots. The whole complex was successfully aligned to self-assembled fibrils of beta-amyloid (one of the key proteins in the development of Alzheimer’s disease). The fibril pattern could then be clearly monitored under a fluorescent microscope and atomic force microscope. The design successfully applied self-assembled DNA origami in biomedical detection, showing results in a stable, fast, and accurate manner, which could assist in clinical diagnosis and contains significant research value in drug delivery and inhibiting the fibrillization of beta-amyloid.

The students are Zou Yukai (Applied Biology, Year 3), Liang Tianlun (Chemistry, Year 3), Sun Xizhen (Computer Science, Year 3), Leng Houfu (Chinese Medicine and Biomedical Science, Year 4), David Chan (Applied Biology, Year 3), Zhang Junqing (Chinese Medicine and Biomedical Science, Year 4).

Team leader, Zou Yukai said: “Self-assembled DNA origami is a novel concept and there are only a few specialists and limited resources to conduct related research in Hong Kong. Our team was pleased to gain the full support of many professors and researchers at HKBU as well as a good collaboration opportunity with researchers from City University of Hong Kong. We believed that this collaboration helps promote the development of inter-institutional scientific research.”

He recalled that after the team was formed, members read a lot of reference material and undertook trial-and-error experiments in laboratories throughout the summer. They overcame many obstacles to achieve the overall positive experimental results. They cooperated very well in the new semester in designing their project’s website, Youtube video, T-shirts, and eventually the project presentation delivered at Harvard University in the US. He added: “The process was a memorable experience for all of us, and it has been full of hard work, encouragement, learning and growth.”

The project’s video designer, Zhang Junqing said: “We made things possible with limited experience. The process also allowed me to fully demonstrate my ability in design and creativity.”

Team member Sun Xizhen said: “I was glad to contribute what I learnt from my specialty in Information Systems to biological engineering in this project. I believe that this cross-disciplinary experience would benefit my future career.”

Details on the HKBU team’s project can be found at: http://openwetware.org/wiki/Biomod/2013/HKBU

六位來自四個不同專業的浸大學生組成「The Rising Power」隊伍,憑著專案設計在二零一三年國際生物分子設計比賽中奪得銀獎。今年,來自九個國家共二十六支隊伍參賽,浸大隊是比賽中唯一獲獎的香港隊伍。

浸大隊設計了一個「自摺疊去氧核醣核酸(DNA)的生物標記分子」,與量子點結合後,能夠成功標記出乙型澱粉樣蛋白(beta-amyloid)的纖維(乙型澱粉樣蛋白是導致認知障礙症的成因之一),並在螢光顯微鏡和原子力顯微鏡下清晰成像。設計成功在生物醫學檢測上應用「自摺疊DNA」,並能穩定、快速、精確地顯示結果,不單有助醫療診斷及症狀評估,且在藥物輸送和抑制乙型澱粉樣蛋白纖維化方面具有研究價值。

隊員包括鄒煜凱同學(應用生物三年級)、梁天倫同學(化學三年級)、孫希震同學(計算機科學三年級)、冷厚甫同學(中醫及生物醫學四年級)、陳宗駒同學(應用生物三年級)及張珺卿同學(中醫及生物醫學四年級)。

隊長鄒煜凱同學說﹕「自摺疊DNA是一個嶄新的概念,本港現時缺乏專家和資源從事這方面的研究。這次比賽我們得到多位浸大教授和研究人員的支持,亦與香港城市大學的科研人員有良好的合作機會,我深信這有助促進大專院校間的科研發展。」

他回想在組隊初期,隊員花了整個暑假閱讀很多參考資料,並埋首於實驗室反覆測試,克服多個難關,終於獲得成功的實驗結果。新學期開始後,隊員間配合得更有默契,從設計網站、製作宣傳短片和團隊服等,並最終遠赴美國哈佛大學演說項目成果。鄒同學說﹕「整個過程充滿了努力、鼓勵、學習和成長,對我們來說是一個非常美好並難忘的經歷。」

負責製作宣傳短片的張珺卿同學說﹕「儘管經驗有限,我們仍成功完成任務。過程亦給予我一個天馬行空、讓我盡情發揮創意的平台。」

隊員孫希震同學說﹕「我很高興能夠將專科所學的(資訊系統)貢獻到生物工程這個項目。我相信這次跨學科研究的經驗,對我未來的發展一定有很大的幫助。」

有關他們的專案設計可瀏覽:http://openwetware.org/wiki/Biomod/2013/HKBU