The research team led by Professor Li Min (fourth from right) is delighted to win the Best Poster Award at the 1st National Congress of Autophagy


李敏教授 (右四) 的研究團隊喜獲第一屆國際細胞自噬會議頒發最佳海報獎

Date: 13 Sep 2017 (Wednesday)

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SCM research team wins Best Poster Award at National Congress of Autophagy

中醫藥學院研究團隊獲中國細胞自噬會議頒發最佳海報獎

Professor Li Min and her research team from the Mr and Mrs Ko Chi Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine (SCM), recently attended the 1st National Congress of Autophagy held in Dalian, China, and won the Best Poster Award for the project entitled “NRBF2 is involved in the degradation process of APP-CTFs in Alzheimer disease models”. Presented by Dr Yang Chuanbin, one of the research team members, the poster was selected as one of the three best posters out of the pool of presentations at the symposium. The project was jointly conducted by Professor Li’s team together with Dr Lu Jiahong from the State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau.

Autophagy is a conserved process that degrades long-lived proteins and damaged organelles mediated by lysosomes, which is involved in many diseases including neurodegerative diseases. Professor Li’s team has been actively engaged in investigating the roles of autophagy dysfunctions in neurodegenerative diseases and the identification and development of novel autophagy regulators derived from Chinese medicines for the prevention and treatment of neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease (AD).

Accumulating evidence indicates that autophagy plays an important role in regulating Alzheimer’s disease pathogenesis. Professor Li said: “We have found that NRBF2 (nuclear receptor binding factor 2), a key component and regulator of the PtdIns3K, is crucial in regulating amyloid beta peptide (Aβ) homeostasis via modulating autophagy. Our results suggest that modulation of NRBF2 may serve as a novel potential therapeutic target for regulating Aβ homeostasis and even AD treatment. This award attests to the hard work and advancement made by the School in the field of autophagy and neurodegenerative diseases at the international level.”

中醫藥學院高智明伉儷柏金遜症研究中心李敏教授的研究團隊最近出席在內地大連舉行的第一屆國際細胞自噬會議,成員楊傳彬博士於會上發表題為「NRBF2通過自噬調節阿爾茨海默病模型中APP C末端片段(APP-CTFs)的降解」的研究海報,從多篇研究海報中脫穎而出,贏得「最佳海報獎」,是三篇得獎作品之一。該研究是李敏教授團隊與澳門大學中藥質量研究國家重點實驗室、澳門大學中華醫藥研究院路嘉宏博士課題組共同合作的。

自噬是細胞一種高度保守的內環境穩定機制,細胞通過自噬將長壽命的蛋白質和受損細胞器運送到溶酶體進行降解,以維護細胞的正常功能和新陳代謝。李敏教授的團隊一直致力研究自噬-溶酶體失調在神經退行性疾病中的發病機制,以及篩選和開發源自中草藥的新型細胞自噬調節劑,以預防和治療包括柏金遜症和阿爾茨海默病在內的神經退行性疾病。

自噬在阿爾茨海默病的發生和發展中具有重要作用。李教授說:「我們團隊發現的PtdIns3K復合物中主要成分之一NRBF2(核受體結合因數2)通過自噬調節APP-CTFs和的β-澱粉樣蛋白(Aβ)的穩態平衡,提示NRBF2有可能成為調節Aβ進而治療阿爾茨海默病的潛在靶點。該獎項充分證明浸大中醫藥學院在細胞自噬、神經退行性疾病等領域處於國際水平。」