The winning team (second from left) Zhang Yilin, Xu Xinzhou, Yu Jucheng, Liu Shihan and Wong Lok-tong win two awards at the 2016 International Bio-molecular Design Competition


(左二起)得獎隊員張逸琳、許新洲、余炬成、劉士菡與黃樂彤為校增光,勇奪2016年國際生物分子設計比賽兩獎項

Date: 11 Nov 2016 (Friday)

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HKBU students win two awards at international competition for their innovative Chinese medicine research proposal

浸大生創新中醫藥研究專案贏美國國際生物分子設計比賽兩獎項

A team of five HKBU students, named “HK-BUddy”, scored impressive successes in the 2016 International Bio-molecular Design Competition held in the US. The team won two awards: the Gold Project Award and 2nd Place in the Project Video competition for their innovative research proposal for Chinese medicines. They beat 30 teams comprising 200 students from more than 10 countries, and their success was the best result achieved by an HKBU team in this competition.

The HKBU team comprised Liu Shihan (Computer Science, Year 4) and four Year 5 students majoring in Chinese Medicine and Biomedical Science: Xu Xinzhou, Zhang Yilin, Yu Jucheng and Wong Lok-tong. Entitled “A smart anti-tumour, nucleolin aptamer-paclitaxel conjugate”, the award-winning proposal demonstrated that the synthesis of nucleolin aptamer-paclitaxel conjugate (NucA-PTX) can break down the limits imposed by paclitaxel alone by effectively enhancing its water-solubility and tumor-targeting capacity. Important features of NucA-PTX are its high stability, low antigenicity and high capacity for cell penetration. It is also easy to modify and synthesise. As a result, the synthesis of NucA-PTX will strikingly improve the tumour selectivity of paclitaxel as a widely-used and effective anti-cancer agent.

Under the supervision of Dr Zhang Ge, Director of the Technology Development Division, School of Chinese Medicine, and Dr Li Fangfei, Research Assistant Professor of the Institute of Integrated Bioinformedicine and Translational Science, the team devoted huge efforts over more than half a year to prepare for the competition. What particularly impressed the judges were the team’s innovative initiatives, confidence and optimistic spirit. 

Xu Xinzhou said the team’s name, “HK-BUddy”, shows how proud they are to be HKBU students. For their presentation at the competition the team used a high-end movie production software, which they were not familiar with, to produce a project video. They were delighted that, thanks to their perseverance in their studies and by conducting repeated tests, they were finally able to complete the entire project.

Xinzhou said it was an honour for the team to work with Dr Zhang Ge and Dr Li Fangfei who taught them many skills and much valuable research knowledge. He would also like to express the team members’ sincere appreciation to the School of Chinese Medicine, the Knowledge Transfer Office, and the Office of Student Affairs for their generous support and assistance throughout the competition.

Details of the HKBU team’s project can be found at: http://www.hk-buddy.com/.

浸大五位同學早前組成隊伍「HK-BUddy」參加在美國舉行的2016年國際生物分子設計比賽,他們從來自逾10個不同國家合共200名學生組成的30支參賽隊伍中脫穎而出,憑著創新的中醫藥研究專案設計,成功贏得比賽金獎和短片製作第二名,為浸大取得歷年來的最佳成績。
 
浸大代表隊成員包括四位中醫及生物醫學五年級同學許新洲、張逸琳、余炬成、黃樂彤與計算機科學四年級劉士菡同學。他們的得獎專案名為「紫杉醇──適配子偶合物的研究計劃」,研究發現合成適配子──紫杉醇偶合物能有效提高紫杉醇的水溶性和腫瘤靶向性,化學穩定性高、免疫原性和毒性低,而且分子量小易於被細胞吸收,亦便於合成和修飾,因此能顯著提升紫杉醇作為最有效抗癌藥物的療效。
 
代表隊在中醫藥學院技術開發部主任張戈博士和整合生物信息醫學與轉化科學研究所研究助理教授李芳菲博士的指導下,用了半年時間為比賽作準備,他們的創新意念、自信和樂觀精神贏得評審的肯定。許新洲同學表示,隊員對身為浸大生引以自豪,因此取名「HK-BUddy」。在比賽期間,同學們運用了不擅長的高科技軟件製作短片配合演說,透過不斷學習和嘗試,最終都能順利完成整個專案設計。

許同學表示榮幸能跟張戈博士和李芳菲博士學習,從二人身上學到不少寶貴的研究知識和技巧。他並衷心感謝中醫藥學院、知識轉移處和學生事務處給予他們的支持與協助。
  
有關「HK-BUddy」的得獎專案設計,可瀏覽網頁:http://www.hk-buddy.com/